Formulation And Activity Test Of Acnes Serum Bidara Leaf Extract (Ziziphus Mauritiana) Against Propionibacterium Acne Bacteria

Abstract

Bidara leaf (Ziziphus mauritiana) is a plant that has antibacterial activity, one of which is against Propionibacterium acne bacteria. Therefore, it can be formulated as an active ingredient in serum preparations. This study aims to formulate Bidara leaf extract and test its antibacterial activity against Propionibacterium acne bacteria using the disc diffusion method. In this study, 4 formulations were prepared with different concentrations of Bidara leaf extract (Ziziphus mauritiana). Then physical stability test was conducted with test parameters including organoleptic, homogeneity, spreadability, pH, irritation. The results of the study based on physical stability test showed that organoleptic, pH, spreadability, irritation, for 4 formulations were stable during storage. Furthermore, based on the antibacterial test of acne serum against Propionibacterium acne, it was found that the concentration of Bidara leaf extract affects the inhibition of the growth of Propionibacterium acne bacteria with an inhibition of 13,3 mm for a concentration of 2.5%, 14,5 mm for a concentration of 5%, and 14,83 mm for a concentration of 7.5%.