Effectivity Test Of Mahoni (Swietenia Mahagoni) Tree Extracts On Animals (Mus Musculus) As Diuretics

Abstract

Hypertension is a condition where a person experiences an increase in blood pressure above normal with systolic pressure above 140mmHg and diastolic pressure above 90mmHg. Hypertensive disease is an important health problem throughout the world with a high and increasing prevalence. Treatment that can be done is by means of herbal medicine using mahogany fruit seeds which contain bioactive compounds including alkaloids, flavonoids tannins, and saponins. This study aims to determine whether mahogany fruit seeds can increase urine volume in mice and at what concentration mahogany fruit seed extract can provide pharmacological effects on mice. The type of research used is experimental with the population of mahogany fruit seeds (Swietenia mahagoni) obtained from the city of Palopo and the sample used mahogany fruit seed extract (Swietenia mahagoni). The data obtained were analyzed using one-way Anova.  From the results of the study obtained diuretic activity of the extract with a dose of 100mg / kgBB as much as 2.5, extract dose of 200mg / kgBB as much as 4.6 and extract dose of 300mg / kgBB as much as 4.5 which means that the three doses have strong activity. In the statistical test results of the average urine volume obtained a significant value of p0.004 (p <0.05). meaning that there are differences in urine volume in the five treatment groups tested proved to have a significant effect on the urine volume of mice.