Gel Formulation of Kersen Leaf Ethanol Extract (Muntingia calabura L.) as Anti-inflammatory in Mice (Mus musculus)

Abstract

Kersen (Muntingia calabura L.) is a type of neutropic plant that can grow well in the tropics. Its leaves have pharmacological effects such as antipyretic, antibacterial, antidiabetic, cardioprotective, antiulcer, antioxidant and anti-inflammatory. The chemical compounds contained in kersen leaves are saponins, tannins and flavonoids. Anti-inflammatory is the name for drugs or agents that work against or suppress the inflammatory process. Gel is a semi-solid preparation that is clear, contains active substances, is translucent and is a colloidal dispersion that has a strength caused by a network that binds together in its dispersed phase. The method used in this study was experimental using mice as experimental animals induced by egg albumin. The results showed that the three formulas had activity as anti-inflammatory and the gel preparation was stable during storage which was characterized by no significant changes in the preparation. So it can be concluded that the kersen leaf ethanol extract gel preparation that provides the best activity is F3.