Effect Of Red Spinach Leaf Infusa (Amaranthus Tricolor) On Reducing Blood Glucose Levels In Mice In Vivo

Abstract

This study was conducted as an effort to preserve natural materials that have the potential as antidiabetics, namely red spinach leaves (Amaranthus tricolor), containing chemical compounds such as flavonoids, tannins, phenols, alkaloids and saponins that can reduce blood glucose. This study aims to determine the effect of red spinach leaf infusa in reducing blood glucose levels and the most effective concentration to reduce blood glucose. Conducted at the Pharmacy Laboratory of Muhammadiyah University of Palopo in August 2023. It is a type of experimental research with the stages of sampling, making infusa of red spinach leaves (Amaranthus tricolor), making 1% na CMC solution, making glibenclamide suspension, making glucose solution as an inducer of test animals. It takes 3 days in the treatment of mice by measuring blood glucose levels. The results of blood glucose reduction obtained are in negative control at 15.40 mg/dL, positive control at 57.40 mg/dL, 20% infusion at 42.13 mg/dL, 25% infusion at 58.20 mg/dL and 30% infusion at 58.27 mg/dL. From the results of the one way ANOVA test and continued with the Duncan test, the results varied or significantly different between the negative control and the treatment groups (positive control, 20%, 25% and 30% infusion). It was also concluded that the most effective in reducing blood glucose levels was 30% infusa with an average value of 58.27 mg/dL.